Its origin might be related to point mutations or might be inherited from parents

Genetic disorders and Primary Ovarian Insufficiency 

There are multiple types of genetic disorders but, as far as feminine fertility is concerned, the most important ones are disorders affecting the X chromosome. The key that this disorders are the principal cause of a phenomenom going by the name of Primary Ovarian Insufficency (POI), also known as Premature Ovarian Failure.

This phenomenon is defined by a loss of ovarian function before menopause, causing irregular periods and a reduction on fertility


Some examples of genetic disorders affecting the chromosome X and, consequently, causing POI are:


This disorder consists on the parcial or complete lacking of one X chromosome in women. In a 96% of the cases the ovarian function of these patients is altered. Aproximately the 2-7% will be able to conceive spontaneously, but the miscarriage and deformity rates are above-average.

This disorder is a consequence of an excessive number of copies of one mutation on the short arm of the X chromosome. While the normal patients have around 6-50 copies of this mutation, those with 55-200 copies will be considered carriers of this disorder. Women who have this disorder, have more than 200 copies, and are defined by a lower ovarian reserve.

Other situations