Gonadotoxic therapies

These therapies are principally indicated in situations of oncological diseases; cancer and neoplasms.

The most well-known are chemotherapy and radiotherapy. Both result in the same situation; the appearance of a Primary Ovarian Insufficiency (POI) phenomenom.


The agents used in chemotherapy, depending on their characteristics, they might affect by:

1- Inducing the occurrence of aneuploidies.

2- Causing oocyte loss and reducing the ovarian reserve.

3- Inducing mutations in these germs cells. 

On another note, the ionizing radiation, used in radiotherapy, affects by:

1- Producing ovarian damage.

2- Provoking atrophy and a decrease in the ovarian reserve.

3- Disturbing the uterus thus preventing the implantation


We can consider those genital tract procedures as treatments that have an effect on feminine fertility. Surgeries that require the removal of any reproductive organ, for example with oncological patients, will have a clear impact on the fertility.


Furthermore, fertility might be diminished by surgical interventions aimed to confront benign neoplasms or diseases such as endometriosis and fibroids if any accidental cut on the ovarian tissue or any ovarian damage due to the cauterization would occur.

Other situations